I assume you have support features in your box that touch the backside of your shells to limit deformation.
I would probably consider adding some fiberglass directly to the back side of your shells to stiffen up the edges for better seal compression in the areas between your fasteners.
I have had pretty good luck sealing molds using elcheapo santoprene foam weather stripping. A super curved shape and a heavy fill like yours probably needs to use round seals sitting in a channel built into one of your shells. You might have to spray on a mold release on the seals to get the longest life out of them. Also might consider using silicone based seals if you need stiffer seal.